Effect on pregnancy outcomes Leflunomide is a new disease-modifying antirheumatic drug. Its immunosuppressive effects are mediated by inhibition of de novo pyrimidine synthesis. Pyrimidines (cytosine and thymine) and purines (adenine and guanine) are the nucleotide bases of DNA. Other mechanisms of action of canadian leflunomide are inhibition of the activity of protein tyrosine kinases, inhibition [...]

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