It has been known for some time that colesevelam (Wel-Chol, Sankyo), a bile acid-binding resin indicated for lowering low-density lipoprotein-cholesterol (LDL-C) levels, reduces glucose levels in individuals with type-2 diabetes. Given that a proportion of this population cannot use generic metformin (Glucophage canadian, Bristol-Myers Squibb) because of elevated cre-atinine values, and given that another group [...]

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Intensive Insulin Therapy
To help patients meet their glycosylated hemoglobin (HbA1c) goals, more of them should be using basal-bolus, or “intensive,” insulin. With intensive insulin treatment, patients give themselves an injection of short-acting insulin before each meal and an injection of longer-acting insulin before going to bed.

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The side-effect profiles of anidulafun-gin and its comparator, fluconazole, seem very similar (Table 4). In clinical studies, oral fluconazole canadian was associated with a higher incidence of hepatic ADEs than anidulafungin, although these differences are probably not clinically significant.

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Esophageal Candidiasis
Krause and colleagues conducted a multicenter, randomized, double-blind, double-dummy, non-inferiority study to compare the efficacy and safety of IV anidulafungin and oral fluconazole (Diflucan drug, Pfizer) for the treatment of esoph-ageal candidiasis. The study took place in the U.S., South Africa, Thailand, and Argentina. A total of 300 patients were randomly assigned to receive [...]

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Anidulafungin is an echinocandin anti-fungal agent used for intravenous (IV) infusion. It is chemically designated as C58H73N7O17, and its molecular weight is 1140.3. This white to off-white lyophilized powder is available as a single-use, 50-mg vial that is supplied with an accompanying 15-ml diluent vial (20% weight in weight [w/w] dehydrated alcohol in water, or [...]

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INTRODUCTION
Over the last 25 years, the incidence of fungal infections has increased dramatically. Predominantly a nosocomial complication, invasive fungal infections are growing in the expanding population of at-risk hospitalized patients. The greatest risk lies in the ever-increasing number of immunocompromised patients, including patients with human immunodeficiency virus (HIV) infection and those receiving chemotherapy or other [...]

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Six years ago, a letter to the editor was published in The New England Journal of Medicine from a physician who suggested using metal detectors to prevent the risk of injuries from metal objects during magnetic resonance imaging (MRI). Unfortunately, his suggestion was spurred by the tragic death of a six-year-old child in New York [...]

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