Intention-to- Treat Analysis A total of 367 patients were randomized (182 to iodinated glycerol and 185 to placebo) for inclusion in the intention-to-treat analysis; of these, six patients (two iodinated glycerol, and four placebo) did not meet the entry criteria and were discontinued from the study before treatment began. Therefore, a total of 361 patients [...]

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Primary and Secondary Efficacy Parameters (Table 1) The eight primary efficacy parameters included assessments of the following: cough frequency, cough severity, chest discomfort, and dyspnea at visits 1, 2, 3; and the patients’ evaluation of the ease of raising sputum, patients’ global assessment and physicians’ global assessment at visits 2 and 3; and a derived [...]

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Study Population Male and female ambulatory outpatients, aged 29 to 83 years, who had chronic stable bronchitis, as defined by criteria of the American Thoracic Society, entered this eight-week study. All candidates admitted to bringing up mucus on most days, but many also complained of cough with difficult expectoration after waking in the morning, or [...]

Continue reading " The National Mucolytic Study Results of a Randomized, Double-Blind, Placebo-Controlled Study off lodinated Glycerol: PATIENTS AND METHODS "

Chronic obstructive bronchitis within the spectrum of chronic obstructive pulmonary disease (COPD) occurs as a result of a complex interplay of inflammatory and morphologic changes in the airways and an associated loss of ciliary function. Obstruction of the peripheral airways appears to be a major cause of airflow limitation. Mucus gland hypertrophy and hyperplasia, and [...]

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We were unable to evidence any correlation be­tween viral shedding and CMV serology; this may be due to the lack of sensitivity or specificity of the complement-fixation test or to a lack of serologic response from critically ill patients. Conversely, we observed a significantly higher rate of viral infection in female patients. While it is [...]

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As early as 1968, blood transfusions used in cardiac surgery had been shown to be associated with risk of CMV infection, as evidenced by CMV serologic re­sponse; however, the incidence of reported CMV infection fluctuates between 40 percent in earlier studies and 1.5 to 12 percent in recent reports and, when considering only viremia, between [...]

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Morbidity Laboratory abnormalities are shown in Table 2. The incidence of atypical lymphocytosis was significantly increased in VE 4- patients, compared with VE — patients (55 percent [16/29] vs 30 percent [26/86], respectively; p<0.05), especially when considering a threshold above 200/cu mm (31 percent [9/29] vs 7 percent [6/86], respectively; p<0.01). Frank mono- nucleosis-like reaction [...]

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