Effect on pregnancy outcomes Leflunomide is a new disease-modifying antirheumatic drug. Its immunosuppressive effects are mediated by inhibition of de novo pyrimidine synthesis. Pyrimidines (cytosine and thymine) and purines (adenine and guanine) are the nucleotide bases of DNA. Other mechanisms of action of canadian leflunomide are inhibition of the activity of protein tyrosine kinases, inhibition [...]

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In 1991, Frank A. Lederle identified highdose oral vitamin B12 (cobalamin) treatment for pernicious anemia as “medicine’s best kept secret.” Lederle noted that only mg of cobalamin is required for daily metabolic functions. Because 2.0% of oral vitamin B12 is absorbed by small bowel mucosa independent of intrinsic factor or the terminal ileum, a daily [...]

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I read with great consternation the article “Raloxifene. Not better than estrogen,” translated from the French La revue Prescrire. As an article in a journal that is designed to keep Canadian family physicians up-to-date on the latest medical information, it leaves much to be desired. Without going into great detail, below is an outline of [...]

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