The appearance of dedifferentiated foci varies more than has been acknowledged in the past. In the report by Henricks et al, the most common pattern was that of a high-grade malignant fibrous histiocytoma consisting of atypical spindle cells and pleomorphic cells arranged haphazardly or in short fascicles. In a few tumors, the dedifferentiated area was [...]

Continue reading " A Case of Dedifferentiated Liposarcoma That Developed in the Dermis: DISCUSSION part 2 "

Liposarcoma is a heterogenous group of malignant mesenchymal neoplasms that exhibit varying de­grees of adipocytic differentiation. The anatomic distribution of liposarcoma appears to be partly related to the histologic type: well-differentiated liposarcoma tends to occur in the deep soft tissues of both the limbs and the retroperitoneum; myxoid/ round cell and pleomorphic liposarcomas exhibit a [...]

Continue reading " A Case of Dedifferentiated Liposarcoma That Developed in the Dermis: DISCUSSION "

A 40-year-old Korean woman presented to our dermatology clinic with a skin lesion on the right thigh, and this lesion had developed 5 years previously. She noticed a recent increase of its size and the development of tenderness. Her personal and family histories were not remarkable. The physical examination revealed a 9 mm-size dome- shape [...]

Continue reading " A Case of Dedifferentiated Liposarcoma That Developed in the Dermis: CASE REPORT "

INTRODUCTION Liposarcoma is the most common soft tissue sarcoma, accounting for 20% of all the soft tissue malignancies in adults. The anatomic distribution of liposarcoma depends largely on the histologic subtype, but the deep soft tissue of the extremities and the retroperitoneum are the most frequently affected sites. Whereas it is accepted that liposar­coma rarely [...]

Continue reading " A Case of Dedifferentiated Liposarcoma That Developed in the Dermis "

Kaposi’s sarcoma (KS) is a lympho-angiopro- liferative disease, having four variants; epidemic or AIDS-associated KS, endemic or African KS, iatro­genic immunodepression-associated KS and Medi­terranean or classical KS (CKS). Classical KS is characterized by single or multiple pea-sized bluish- red macules on the distal portions of the lower extremities.

Continue reading " Recurrent Classical Type of Kaposi’s Sarcoma Treated by Interferon-a: DISCUSSION "

Patient: A 58 year-old male Chief complaint: A tender, firm, erythematous nodule with surrounding small papules and macules on the right sole for 6 months Physical examination: A 1.2 cm sized, firm, dome shaped, erythematous nodule and multiple, 7 ~8 mm-sized, satellite purplish macules and papules (Fig. 1A)

Continue reading " Recurrent Classical Type of Kaposi’s Sarcoma Treated by Interferon-a: CASE REPORT "

INTRODUCTION Kaposi’s sarcoma (KS) is a rare lympho-angio- proliferative disease. Classical KS usually appears in elderly Eastern European Jewish or Mediterranean men, with male to female ratio of approximately 3 : 1. It is clinically characterized by single or multiple pea-sized bluish-red macules on the distal portions of the lower extremities. The lesion usually progresses [...]

Continue reading " Recurrent Classical Type of Kaposi’s Sarcoma Treated by Interferon-a "