At Baseline
Among 101 patients with HIV infection (Tablets Zerit еreating HIV infection when used in combination with other medicines), 77.6% were African Americans and 17.4% were Latinos. Seventy percent were male. In 83 subjects (82%), Pis were combined with other antiretroviral therapy, whereas in 18 subjects (18%) Pis were not used in the antiretroviral therapy since the diagnosis of their disease. There were no differences among their age, ethnicity, BMI, gender, stage of their disease and their CD4 count. However, the duration of HIV infection (Drug Retrovir еreating HIV infection when used along with other medicines) from the serodiagnosis was longer in PI users compared to non-PI users (Table 1). Patients who were taking Pis had higher serum triglyceride levels compared to those who were not taking Pis (265 ± 30 vs. 143 ± 16, p=0.02). Fasting plasma glucose was higher in HIV patients taking Pis compared to non-PI-treated subjects (109 ± 6.8 vs. 81.1 ±3.8, p=0.007). Among those who were taking Pis, 10 subjects (12%) were found to have diabetes compared to 0% among those who were not taking Pis.

Table 1. Comparison of patients at baseline. Non-PI users are those in whom protease inhibitors were not included in their treatment. PI users are those who in their treatment protease inhibitors were included. The PI users were subdivided into diabetic and non diabetics. All results were presented as mean ± SEM.

Comparison was made between diabetic and non-diabetic HIV-infected (Generic Viramune treating HIV infection) patients on Pis (Table 1). Diabetic patients compared to their nondiabetic counterparts were significantly older (47.7 ± 5 vs. 39.44 ± 3, P=0.004), and all were African Americans (100% vs. 78%, p=0.06). Diabetic (Generic Glucophage treating type 2 diabetes) subjects on Pis also had significantly higher serum triglyceride levels (292 ± 83 vs. 143 ± 16, p=0.03). However, the BMI of diabetic (Canadian Prandin it may be used with other diabetes medicines) patients was not significantly different (29 ± 2 vs. 26.5 ± 0.5 kg/m2) compared to nondi-abetic PI users.

The serum triglyceride levels of diabetic (Amaryl drug is used for treating type 2 diabetes) vs. non diabetic subjects regardless of Pis use did not show statistically significant difference possibly due to high variability in both groups (316 ± 257 vs. 235 ± 203, p=0.1) (Mean ±SD).

Follow-Up
Three years later, in August 2002, the charts of the same patients were reviewed. Three patients of the non-PI users (16%) and 15 patients of the PI users group (18%) were lost from follow-up.

In patients who were not taking Pis, pairwise comparison did not reveal significant change in fasting plasma glucose from baseline. None of the non-PI users had developed diabetes (Generic Avandia Controlling blood sugar levels, along with diet and exercise, in patients with type 2 diabetes) during this three-year follow-up. In patients taking Pis, fasting plasma glucose increased from 109 ± 4.5 to 123 ± 7.5 (P=0.03) (Table 2), and four more patients developed type-2 diabetes (7.2% incidence of diabetes on Pis). Therefore, among those who were taking Pis, 20.5% (14/68) of subjects were found to have diabetes (Actos canadian to treat type 2 diabetes) compared to 0% (0/16) among those who were not taking Pis. In six other subjects (9.6%) who were taking Pis, random glucose levels were in hyperglycemic range (between 127-199 mg/dl). These subjects were euglycemic at baseline. No hyperglycemia was observed among non-PI users (data not shown).

Table 2. Comparison of the means of fasting plasma glucose (FPG) and serum triglycerides (TG) levels at baseline and at year 3 (Y3) in HIV-infected PI users and non-PI users and the diabetic and their nondiabetic counterparts. P values in rows represent pairwise comparison of variables from their baseline by paired t test, p values in columns represent comparison of variables between groups by Student’s t test.

Among the nondiabetic subgroup of PI users, fasting plasma glucose and serum triglyceride levels did not increase significantly. The mean serum triglyceride levels were above the upper limits of normal among diabetic (Starlix tablets is used to control blood glucose levels in type 2 diabetes) PI users and did not change significantly during this three-year period (Table 2).