Introduction Vitamin D receptor (VDR) is the responsible of much of the vitamin D [1,25-(OH)2D3] signalling. It is a direct regulator of gene transcription, belonging to the nuclear receptor family. Within this family, it has sequence and structure resemblance with the subfamily that includes retinoic acid, thyroid hormone and peroxisome proliferator activator receptor (PPAR) receptors. [...]
Continue reading " The vitamin D receptor: biological and molecular properties "
Possible Explanations for G894T Genotype Effects Existing data in certain models of hypertension have shown that a relative or absolute defect in the production of NO by NOS is associated with various degrees of end-organ involvement in response to hemodynamic workload. Since NO may participate in the hypertrophic growth of the myocardium independently of its [...]
G894T Genotype Influences LVM in Borderline Hypertension High-normal Blood Pressure was used as a model of borderline hypertension to examine the early influences of both BP and the G894T polymorphic variant of the eNOS gene on echocardiographically determined LVM. We found an increase in LVM in individuals who have high-normal BP and carry the 894T [...]
Continue reading " African Americans with high-normal blood pressure: DISCUSSION "
Characteristics of Subjects by Blood Pressure Status Table 1, which shows no significant differences in each category lists the clinical characteristics of the subjects.
Continue reading " African Americans with high-normal blood pressure: RESULTS "
Genotyping of the eNOS Polymorphism DNA was extracted from the whole EDTA blood by means of a standard procedure (QIAmp Blood Kit, Qiagen). The variant of eNOS gene being analyzed is the G894T, in which a substitution of G to T at nucleotide position 894 results in a replacement of glutamic acid for aspartic acid [...]
Study Sample The study consisted of self-reported African Americans selected from a larger population-based cohort of participants aged 18 years or older who were consecutively recruited from barbershops, shopping malls, churches, community organizations/centers and health fairs in the south and southwest metropolitan of Atlanta. Ninety healthy nor-motensive subjects (54 females and 36 males, mean age [...]
Continue reading " African Americans with high-normal blood pressure: METHODS "
Blood pressure (BP) in the high-normal range is now considered a prehypertensive state/borderline hypertension, and its importance as a risk factor for the development of cardiovascular (CV) disease has been consistently demonstrated across various populations. Longitudinal data from the Framingham Heart Study have recently indicated that men and women with an initial high-normal BP had [...]
Continue reading " African Americans with high-normal blood pressure "
