In 1991, Frank A. Lederle identified highdose oral vitamin B12 (cobalamin) treatment for pernicious anemia as “medicine’s best kept secret.” Lederle noted that only mg of cobalamin is required for daily metabolic functions. Because 2.0% of oral vitamin B12 is absorbed by small bowel mucosa independent of intrinsic factor or the terminal ileum, a daily [...]

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